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Immune Modulation as a New Direction in IgA Nephropathy Treatment
IgA nephropathy develops when abnormal immune responses cause immunoglobulin A antibodies to deposit within kidney tissues. These deposits trigger inflammation that gradually damages the filtering units known as glomeruli. Because the disease originates from immune dysfunction, treatment strategies increasingly focus on immune modulation rather than simply managing symptoms.
Traditional therapies relied heavily on corticosteroids to reduce inflammation. While these medications can slow disease progression, prolonged use carries risks such as infections, bone density loss, and metabolic complications. As a result, healthcare providers now aim to balance effectiveness with safety by exploring targeted approaches.
Immune modulation therapies attempt to regulate specific pathways responsible for abnormal antibody production. Instead of suppressing the entire immune system, these treatments focus on controlling the mechanisms that cause kidney inflammation. This selective approach reduces unwanted side effects while maintaining protective immune functions.
Patient selection plays a crucial role in determining treatment success. Some individuals experience mild…